Pharmacy Clinic
Treatment of Heart Burn
Drug treatment:

The major agents in the current armamentarium against peptic ulcer disease are:
•        H2-receptor antagonists
•        H+,K+-ATPase (acid pump) inhibitors
•        Sucralfate
•        Antacids
•        Bismuth compounds.

I-        Antacids

II        H2 antagonists

III-Anticholinergics

Muscarinic cholinergic antagonists can reduce basal secretion of gastric acid, selective M1 antagonists are as effective
as atropine or other non selective muscarinic antagonists , but they are less likely to produce the adverse effects that
are occurred usually by cholinergic blockage(dry mouth, tachycardia ).

Muscarinic blocking drugs used for ulcer because they reduce peristaltic movement of G.I.T particularly the intestine
and this is why mainly used for duodenal ulcer.

IV- Sucralfate

is a complex substance formed from a sulfated disaccharide and polyaluminum hydroxide .It polymerizes when the pH
below 4.

The condensed polymer forms a gel, which adhere to the base of duodenal ulcer.

When sucralfate taken before meals, it is effective for the treatment of duodenal ulcer disease.

Sucralfate works by creating a protective coating over the ulcer to protect it from acid and digestive juices, thus
allowing it to heal. It also helps to strengthen the defenses of the stomach lining. Sucralfate may be more effective
than H2 blockers in patients who smoke.

Adverse reactions are minimal because not systematically absorbed.

V-         Prostaglandine E2 analogue

is used as anti ulcer by inhibiting acid secretion and increase mucous release e.g misoprostil.

VI-         Proton Pump Inhibitors "PPIs"


Natural Remedies For Peptic Ulcer